Effect of oxygen-derived free radicals on hyaluronic acid
نویسندگان
چکیده
منابع مشابه
Depolymerisation products of hyaluronic acid after exposure to oxygen-derived free radicals.
Preparative chromatographic fractions of human umbilical cord hyaluronic acid (HA) of a molecular weight of 10(6) were subjected to graded oxygen-derived free radical (oxy radical) fluxes produced by: (a) the autoxidation of ferrous ions; (b) the action of xanthine oxidase (XO) on hypoxanthine (HX); and (c) by peripheral blood polymorphonuclear leucocytes that had been stimulated by phorbol myr...
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Myocardial ischemia and reperfusion can evoke excitation of cardiac vagal afferent nerve endings and activation of a cardiogenic depressor reflex (Bezold-Jarisch effect). We postulate that oxygen-derived free radicals, which are well known to be produced during prolonged ischemia and reperfusion, contribute to this excitation. Hydroxyl radicals derived from hydrogen peroxide (H202) activate abd...
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Hydrogen peroxide destroyed the Na+/Mg2+ antiport in Mg(2+)-loaded human and rat erythrocytes and increased the leakage of intracellular Mg2+ and K+. These effects are opposite to the increase of Na+/Mg2+ antiport and unchanged Na(+)-independent Mg2+ efflux from erythrocytes of patients with cystic fibrosis score 3. Thus, the increase of Na+/Mg2+ antiport in these patients is not caused by incr...
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Pyrogallol (a generator of superoxide anions) caused 50% increase in platelet aggregation induced by 400 microM of arachidonic acid. Dipyridamole did not produce a statistically significant inhibition of arachidonic-acid induced platelet aggregation, but it caused 100% inhibition of pyrogallol-stimulated platelet aggregation. Ferrous salts (Fe2+) induced 34% platelet aggregation which was inhib...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1980
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780230408